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Study Tests Dose and Toxicity Levels of Treatments For Mesothelioma Victims

Article by Peter Kent

A study currently being conducted in Boston, Mass., by several physicians is attempting to determine the highest level of medicinal treatments, such as chemotherapy, that can be administered to mesothelioma victims in order to more adequately treat symptoms of the killer lung disease.

Researchers are using two methods of treatment known as intraoperative intracavitary hyperthermic cisplatin perfusion along with amifostine, to assist in preventing cisplatin toxicity, to patients suffering from malignant pleural mesothelioma, which is often deemed the most severe and fatal diagnosis among mesothelioma patients.

So far the study has found that the use of single dose amifostine does “not protect adequately against cisplatin-induced renal toxicity,” meaning that if higher doses of the chemotherapy treatment cisplatin are used, then “additional cytoprotective strategies are needed” to protect a patient from developing toxic levels of medication in addition to their painful mesothelioma side effects.

What is Mesothelioma?

Mesothelioma lung cancer is a fatal condition that can develop after exposure to asbestos fibers and asbestos dust occurs. It is common for individuals who are employed in the field of construction to be at the highest risk for developing mesothelioma cancer, which often remains dormant for years, eating away at a victims interior until it is too late for successful treatment.

Although those working in the construction industry are at an increasing risk of developing mesothelioma cancer, the risk also stems to their family and friends who become exposed to asbestos after an employee covered in asbestos returns home accidentally exposing family and friends to the fiber.

For those who may be concerned about a mesothelioma diagnosis, they can learn more about the condition by contacting a physician and receiving a physical as well as x-rays to ensure that a proper diagnosis as well as treatment is administered. However, it will still be important for a patient to know and recognize the following mesothelioma signs and symptoms as well. Currently, there are two main types of mesothelioma commonly affecting the lining of the lungs and the internal organs: abdominal and lung. The Mayo Clinic reported the following

* symptoms for both conditions:

* shortness of breath

* painful breathing

* painful coughing

* chest pain under the rib cage

* unusual lumps of tissue under the skin on the chest

* unexplained weight loss

* dry cough

* abdominal pain

* abdominal swelling

* change in bowel habits

* lumps of tissue in the abdomen

If an individual develops any of the above side effects, it is imperative that they receive immediate attention from a doctor. Unfortunately, there is a high rate of death linked to a mesothelioma diagnosis, which is commonly due to the fact the disease remains dormant for several years.

Support For Mesothelioma Victims

Mesothelioma sufferers face many challenges as a part of their diagnosis. In order for a victim to receive adequate mesothelioma treatments they must retrieve medical attention, which will assist in easing the pain and symptoms of mesothelioma.

Additionally, it may be necessary to receive details about the development of a mesothelioma lawsuit from an experienced mesothelioma attorney. Constructing a mesothelioma lawsuit will likely assist a victim in receiving monetary compensation, which can pay for the expensive mesothelioma treatments associated with the disease. For the latest on a mesothelioma diagnosis as well as the development of potential litigation, individuals can discuss a mesothelioma lawsuit with a mesothelioma attorney who can provide the most up-to-date news and information on such a case.

About the Author

LegalView (http://www.LegalView.info ) not only offers a variety of resources for mesothelioma patients at http://mesothelioma.legalview.com, but also provides a full library of legal resources ranging from the latest in traumatic brain injury treatments to developing a Fosamax class action lawsuit.

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Recent Study Finds Multimodal Approach To Mesothelioma Treatment Yields Best Results In 110 Patients Suffering From …
A recent study of 110 patients suffering from malignant pleural mesothelioma has found that although single modality therapy has traditionally been the most common treatment approach, it has largely failed to treat this aggressive cancer, leading to a continued poor prognosis. However, this study, led by Dr. Hesham A. El Hossieny, found that those patients who undergo a multimodal treatment …
Read more on redOrbit

New Leadership for the Organization Leading the Funding of Mesothelioma Research
This week, the Mesothelioma Applied Research Foundation, the leading organization funding mesothelioma research and providing patient services, announced the election of new Co-Chairs of its Board of Directors. (PRWeb January 26, 2011) Read the full story at http://www.prweb.com/releases/2011/1/prweb8090988.htm
Read more on PRWeb

Weitz & Luxenberg Appalled By Undercounting of Worldwide Mesothelioma Cases
NEW YORK–(BUSINESS WIRE)–According to data released by the Environmental Health Perspective (EHP), Mesothelioma cases are either minimally reported, or completely overlooked. It is estimated that as many as 20% of global mesothelioma cases are not reported. The EHP is the first to pioneer such a study, which focused on 89 different nations, including The United States, Canada, Russia, Germany …
Read more on Business Wire

When nonseroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are combined with Piroxicam and cisplatin (CDDP) they produce an anti-tumoral treatment of cancerous cells, specifically malignant mesothelioma cancer cells. These results, published in May 2008 in the Journal of Translational Medicine, are getting plenty of attention by both scientists as well as victims of mesothelioma cancer. Prior to this study, the prognosis for malignant mesothelioma cancer was grim, even at best, but now, researchers are breaking open a can of worms that may provide treatment for the deadly cancer caused by the inhalation of asbestos dust.

While this study offers a slice of hope for victims, the further research is required. Scientists with this study also found that the potential for determining a specific molecular target of mesothelioma cells, because of these drugs’ anti-tumor effects, could lead to advances in therapy treatments of the deadly cancer.

What is Malignant Mesothelioma Cancer?

There are several varieties of mesothelioma cancer, however, malignant mesothelioma is considered one of the most lethal. According to the study, “prognosis is poor and patients have a median survival of a few months in either treated or untreated cases.” Malignant mesothelioma is a rare cancer with malignant cancer cells forming on the sac lining of the chest or abdomen, according to the National Cancer Institute (NCI). It is often associated with exposure to airborne asbestos particles and fibers, which increases the risk of malignant mesothelioma developing in an individual.

Signs and Symptoms of Malignant Mesothelioma

Malignant mesothelioma is often marked by several symptoms including lumps in abdomen, weight loss, pain or swelling in the abdomen, pain under the rib cage and difficulties breathing. The cancer can also often cause fluid retention in the abdomen or around the lungs. The cancer often has symptoms similar to other conditions making misdiagnosis of the condition common.

Medical professionals have even admitted that malignant mesothelioma and lung cancer are very similar and differentiating between the two is difficult, however, there is an array of tests that physicians can use to increase the potential for a more accurate diagnosis. Tests for diagnosis may include the patient enduring physical exams, chest x-rays, biopsy of body tissues, getting a complete blood count (CBC), cytologic exam, which is an exam of cells under a microscope, or a bronchoscopy procedure where a bronchoscope is inserted into the nose or mouth for a better view of airways.

Diagnosing and Treating Malignant Mesothelioma

While treatments for mesothelioma are rare in and of themselves, it becomes increasingly difficult to treat malignant mesothelioma because of the severity of the condition. However, medical professionals take into consideration several factors prior to treatment to determine a patient’s prognosis. The following is a detailed list of these factors, according to the NCI:

* The stage of cancer, which includes stage I or localized malignant mesothelioma or advanced malignant mesothelioma that includes stage II, stage III and stage IV.

* The size of a tumor.

* Potential for tumor removal through a surgical procedure.

* The amount of fluid gathered in the chest or abdomen.

* A victim’s age, physical health and previous health issues.

* Type of mesothelioma cancer.

* Whether a cancer is diagnosed as reoccurring or not.

Often, cancer may spread through the lymph system, blood stream or other bodily tissues.

Treatments for malignant mesothelioma can range from surgery to therapy, including chemotherapy and biological therapy to clinical trials, although the outcome is based on the progression of the cancer and most often, individuals are not aware of their condition until it reaches an advanced and, usually, an untreatable stage.

Asbestos Exposure and What to Do

Asbestos is a mineral fiber that was used heavily in a range of building materials from vinyl flooring to insulation. It was prized for its inexpensive production costs and fire-retardant ability making it ideal among construction companies. Unfortunately, the inhalation of high levels of asbestos dust and fibers contributed to the development of mesothelioma cancer.

Unfortunately, this discovery came far too late, as millions of Americans working in the industry were exposed and millions more continue to remain at risk for exposure as asbestos still exists in homes, schools, apartment complexes and dozens of other types of buildings across the country. Individuals who believe they may have been exposed to asbestos particles and fibers should seek medical attention as soon as possible. If mesothelioma is the outcome it is advisable for a patient to receive consultation from an experienced mesothelioma attorney, as the potential for a mesothelioma lawsuit may exist with the opportunity for monetary compensation.

Researchers recently published the results of a study in the Journal of Clinical Oncology detailing a potentially new treatment for patients of abdominal mesothelioma that will likely improve the condition for patients.

The study found that when patients suffering from abdominal mesothelioma were given a combination of two drugs, Alimta (pemetrexed) and Gemzar (gemcitabine), their condition improved. The following are the results of the study:

* Response rate among patients was 15 percent.

* The control rate of the disease for patients while on the medication was 50 percent.

* The median time to disease progression was 10.4 months.

* The median survival time was 26.8 months.

* The mesothelioma study involved 20 patients suffering from the condition.

Each patient also received various vitamins including folic acid, vitamin B12 and dexamethasone. The study was conducted by researchers involved in a multi-center U.S. trial. Researchers expect to continue studying the drug’s effects on abdominal mesothelioma patients to determine if the treatment can be improved.

What is Abdominal Mesothelioma?

Abdominal mesothelioma is an extremely rare form of mesothelioma cancer. Commonly described as peritoneal mesothelioma, the cancer affects the abdominal lining, which is also known as the peritoneum. Within the abdominal cavity is the serous membrane, which is also known as the parietal peritoneum, and this membrane continues on to the visceral peritoneum that lines the organs. With abdominal mesothelioma, the visceral and parietal peritoneum linings are affected with the development of cancerous cells.

Most often, abdominal cancer occurs when an individual first develops pleural mesothelioma, which is when the lining of the lung develops cancerous cells after inhalation of asbestos. Pleural mesothelioma can then spread to the peritoneal cavity and cause peritoneal mesothelioma, which accounts for less than one-third of all mesothelioma diagnoses.

How is Peritoneal Mesothelioma Contracted?

Abdominal, or peritoneal, mesothelioma is caused through the inhalation of asbestos fibers or asbestos dust. Asbestos is a material that is derived from vermiculite, a mineral that was mined heavily in the United States and around the world in the 20th century. Asbestos was most commonly used as an insulation within the construction industry because it was flame resistant and was developed at inexpensive prices.

There are many common symptoms of mesothelioma, including:

* shortness of breath.

* inability to breath.

* fatigue.

* wheezing or severe cough.

However, many of these symptoms are generalized to overall cases of mesothelioma. Specific symptoms exist for those diagnosed with peritoneal mesothelioma. These symptoms are as follows:

* weight loss.

* abdominal swelling, which can be caused by ascites or the buildup of fluid in the abdominal cavity.

* bowel obstruction.

* fever.

* anemia.

* blood clotting.

* trouble swallowing.

* swelling of neck and face.

Abdominal Mesothelioma Treatment

Abdominal mesothelioma treatments commonly consist of surgical procedures to remove the infected cancerous areas. Often, the main surgery involved with peritoneal mesothelioma is known as cytoreductive surgery. This surgery is usually accompanied with perioperative intraperitoneal chemotherapy, and together the median survival rate for patients has been shown to increase slightly, although, treatment is dependent on a specific case-by-case basis.

Obtaining Peritoneal Mesothelioma Legal Help

Individuals who have been diagnosed with peritoneal mesothelioma or any similar form of mesothelioma cancer are advised to locate an experienced mesothelioma attorney. Because mesothelioma is considered a highly preventable disease, individual victims who contract the illness were likely exposed to asbestos fibers or asbestos dust without knowledge of the danger of exposure levels. These individuals may be able to receive monetary compensation for the extremely costly medical bills associated with abdominal mesothelioma.

It is especially important for an individual to seek legal counsel for their mesothelioma lawsuit if they were an employee within the metal, mining, maritime, construction and welding industries.

Mesothelioma has long been linked to the inhalation and exposure to asbestos fibers and dust, so when scientists uncovered an additional potential cause for this incurable form of lung cancer, the unthinkable became a reality.

According to researchers based out of the Woodrow Wilson International Centre for Scholars in Washington D.C., the early 90′s development of carbon nanotubes has been an amazing feat for technological applications, however, it has not gone without its price. Specifically, carbon nanotubes may be causing harm to the human body in the form of mesothelioma cancer.

If the carbon nanotubes are introduced into the wrong environment, the development of lesions and inflammation of the lungs occurs – symptoms similar to that of mesothelioma cancer and asbestos exposure. Researchers uncovered the finding through exposure of carbon nanotubes to animals.

Dr. Andrew Maynard, who published a study in the journal Nature Nanotechnology, described the use of nanotubes and the potential link to mesothelioma cancer. He said that currently, nanotubes are being implemented because of their awesome abilities at conducting heat and electricity. Mostly, Dr. Maynard explains, the nanotubes are being implemented into sports equipment. He said that there are no regulations as to where nanotubes can be implemented and there are currently no requirements for the use of nanotubes to be disclosed to the general public.

What Are Nanotubes?

According to Maynard, nanotubes are a product of nanotechnology research, one he considers the “poster child” of nanotechnology. The nanotubes are cylindrical structures comprised of carbon atoms that have been rolled together. Maynard’s study found that when mice were exposed to nanotubes, they developed asbestos-induced symptoms within the lungs. While he and other researchers consider nanotubes to be safe – when encased – the risk occurs when nanotubes are incinerated or broken.

Nanotubes are currently being used in:

* a variety of sports equipment

* bicycle frames

* tennis rackets

* electronic gas detectors

* radios

Additionally, because of the strength of nanotubes, many consider its future use to vastly effect several business ventures and areas, and be widely used in industries including:

* aerospace

* automobile

* airplanes

* television box productions

* medical

* environmental uses

Working with Nanotubes

While the National Institute for Occupational Safety and Health (NIOSH) is doing research on nanotoxicology, there is little knowledge or research currently available regarding the safety of using nanotechnology. Additionally, Dr. Maynard noted that because of the ever-increasing nanotechnology industry, which is likely to be worth $2.6 trillion by 2014, it will be difficult to adequately and accurately assess nanotechnology safety because of the technology’s quick growth, which is also being used in the food industry.

Transparency of nanotoxicology among some nanotechnologically-produced products may fall into the hands of manufacturers and producers, which John M. Balbus, health program chief for the Environmental Defense Fund who was interviewed in a Washington Post article on nanotechnology, said could either be a very good thing with open communications, or a very bad thing replicating the mistakes made among the construction industry’s use of asbestos. However, he noted that upfront communication regarding the dangers of nanotechnology with the public may increase because of the previous mistakes made by other industries in hiding mesothelioma conditions from the public.

Finding Help with Nanotube Related Mesothelioma

Individuals, especially nanotube factory workers who have previously worked with carbon nanotubes or have been exposed to the potential dangers associated with the nanotubes and developing mesothelioma should receive medical attention immediately.

It may also become necessary for these individuals to locate a law firm with knowledge of mesothelioma-related litigation in order to develop a mesothelioma lawsuit.

Because of the nature of the industry and the continued funding flooding into carbon nanotube research it is important to develop a lawsuit that will also alert others, in a similar predicament, and provide aware of the potentially serious health risks associated with nanotechnology. Further, because only 5 percent of the funding, which consists of billions of dollars annually, provided by the National Nanotechnology Institute is going toward health and safety research, it is important for individuals with nanotube-induced mesothelioma to develop a lawsuit that may offer monetary compensation to victims suffering from this irreversible and deadly lung cancer.