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Researchers recently uncovered the potential of a cholesterol drug, introduced in the 1980s, that may offer mesothelioma victims an effective treatment for the deadly and incurable cancer. The drug, Lovastatin, is used to treat and control high levels of cholesterol among patients.

Early on, scientists found that in initial studies of the drug, dating back 20 years, it had an unexpected and very powerful effect on killing cancerous cells within humans. At that time, however, the anti-cancer effect was considered too risky to continue studying because of the extremely high doses that were needed to be given to a cancer patient. Researchers put the study on hold, according to news reports, until recently when scientists at a Nashville, Tenn., clinic started providing the drug to pleural mesothelioma patients.

Details of Lovastatin and its Cancer-Killing Potential

Researchers have given little notice to Lovastatin as a treatment for mesothelioma cancer even though a stage-four melanoma patient had received treatments of Lovastatin in 2000 and currently remains cancer-free, nearly nine years later. While researchers are unsure that they can find the same success of the melanoma patient, the use of Lovastatin may potentially reduce or slow the cancerous production of mesothelioma cells, which can kill an individual within as little as one year after symptoms appear.

A study published in the American Journal of Respiratory and Critical Care Medicine found that the cholesterol drug induces apoptosis on mesothelioma cells. Apoptosis is also described as programmed cell death, according to the Reproductive and Cardiovascular Disease Research Group. Apoptosis occurs when a stimuli is introduced to a variety of cells in which the cells begin to commit cell suicide. The study looked at the morophologic changes, histologic evidence of nuclear condensation and degeneration, and flow-cytometric analysis of DNA content of the mesothelioma cancer cells treated with Lovastatin and determined it a potentially sufficient treatment for mesothelioma.

What is Lovastatin?

Lovastatin is part of a group of drugs known as HMG-CoA reductase inhibitors (statins). The drugs decrease the production of bad cholesterol within the body. It is often prescribed to patients as an oral pill that is taken in low-doses — once every four weeks.

Lovastatin does have reported side effects, which have not been fully studied on mesothelioma patients, however, according to the National Library of Medicine (NLM) the side effects include:

* hives, rashes and itching

* loss of appetite

* flu-like symptoms

* nausea as well as pain in upper right part of stomach

* extreme tiredness

* yellowing of skin and eyes

* lack of energy

* difficulty breathing and swallowing

* swelling of face, throat, tongue, lips, eyes, hands, feet, ankles and

* lower legs/calf muscles

* muscle pain, tenderness or weakness

* fever

* unusual bleeding or bruising

* hoarseness

* constipation

What to do If Diagnosed With Mesothelioma

Mesothelioma cancer has become increasingly prevalent in the United States and around the world. Individuals who were exposed to a mineral known as vermiculite containing deadly asbestos may have had the condition for 20 or more years without any signs of the cancer within their bodies.

Once researchers began discovering the link between asbestos exposure and mesothelioma, asbestos was banned in the United States and around the world. However, shipments of asbestos are still being imported into the United States and millions of Americans remain at risk for exposure because of the prevalence of asbestos in many homes, apartments, schools, universities, hospitals and government buildings.

Those who have suffered from mesothelioma cancer or feel they may have been a victim of asbestos exposure have the ability to consult a legal professional for a potential mesothelioma lawsuit. Such litigation may appear overwhelming to a victim, but can potentially offer monetary compensation for the heavy expenses associated with receiving mesothelioma medical treatments. Consulting a mesothelioma attorney is often a free legal service and may add peace of mind for mesothelioma victims, their families and friends.

Researchers recently published the results of a study in the Journal of Clinical Oncology detailing a potentially new treatment for patients of abdominal mesothelioma that will likely improve the condition for patients.

The study found that when patients suffering from abdominal mesothelioma were given a combination of two drugs, Alimta (pemetrexed) and Gemzar (gemcitabine), their condition improved. The following are the results of the study:

* Response rate among patients was 15 percent.

* The control rate of the disease for patients while on the medication was 50 percent.

* The median time to disease progression was 10.4 months.

* The median survival time was 26.8 months.

* The mesothelioma study involved 20 patients suffering from the condition.

Each patient also received various vitamins including folic acid, vitamin B12 and dexamethasone. The study was conducted by researchers involved in a multi-center U.S. trial. Researchers expect to continue studying the drug’s effects on abdominal mesothelioma patients to determine if the treatment can be improved.

What is Abdominal Mesothelioma?

Abdominal mesothelioma is an extremely rare form of mesothelioma cancer. Commonly described as peritoneal mesothelioma, the cancer affects the abdominal lining, which is also known as the peritoneum. Within the abdominal cavity is the serous membrane, which is also known as the parietal peritoneum, and this membrane continues on to the visceral peritoneum that lines the organs. With abdominal mesothelioma, the visceral and parietal peritoneum linings are affected with the development of cancerous cells.

Most often, abdominal cancer occurs when an individual first develops pleural mesothelioma, which is when the lining of the lung develops cancerous cells after inhalation of asbestos. Pleural mesothelioma can then spread to the peritoneal cavity and cause peritoneal mesothelioma, which accounts for less than one-third of all mesothelioma diagnoses.

How is Peritoneal Mesothelioma Contracted?

Abdominal, or peritoneal, mesothelioma is caused through the inhalation of asbestos fibers or asbestos dust. Asbestos is a material that is derived from vermiculite, a mineral that was mined heavily in the United States and around the world in the 20th century. Asbestos was most commonly used as an insulation within the construction industry because it was flame resistant and was developed at inexpensive prices.

There are many common symptoms of mesothelioma, including:

* shortness of breath.

* inability to breath.

* fatigue.

* wheezing or severe cough.

However, many of these symptoms are generalized to overall cases of mesothelioma. Specific symptoms exist for those diagnosed with peritoneal mesothelioma. These symptoms are as follows:

* weight loss.

* abdominal swelling, which can be caused by ascites or the buildup of fluid in the abdominal cavity.

* bowel obstruction.

* fever.

* anemia.

* blood clotting.

* trouble swallowing.

* swelling of neck and face.

Abdominal Mesothelioma Treatment

Abdominal mesothelioma treatments commonly consist of surgical procedures to remove the infected cancerous areas. Often, the main surgery involved with peritoneal mesothelioma is known as cytoreductive surgery. This surgery is usually accompanied with perioperative intraperitoneal chemotherapy, and together the median survival rate for patients has been shown to increase slightly, although, treatment is dependent on a specific case-by-case basis.

Obtaining Peritoneal Mesothelioma Legal Help

Individuals who have been diagnosed with peritoneal mesothelioma or any similar form of mesothelioma cancer are advised to locate an experienced mesothelioma attorney. Because mesothelioma is considered a highly preventable disease, individual victims who contract the illness were likely exposed to asbestos fibers or asbestos dust without knowledge of the danger of exposure levels. These individuals may be able to receive monetary compensation for the extremely costly medical bills associated with abdominal mesothelioma.

It is especially important for an individual to seek legal counsel for their mesothelioma lawsuit if they were an employee within the metal, mining, maritime, construction and welding industries.